No genetic bottleneck in Plasmodium falciparum wild-type Pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance

Chen, Nanhua, Gao, Qi, Wang, Shanqing, Wang, Guangze, Gatton, Michelle L., & Cheng, Qin (2008) No genetic bottleneck in Plasmodium falciparum wild-type Pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance. Antimicrobial Agents and Chemotherapy, 52(1), pp. 345-347.

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Abstract

Chloroquine-resistant Plasmodium falciparum was highly prevalent in Hainan, China, in the 1970s. Twenty-five years after cessation of chloroquine therapy, the prevalence of P. falciparum wild-type Pfcrt alleles has risen to 36% (95% confidence interval, 22.1 to 52.4%). The diverse origins of wild-type alleles indicate that there was no genetic bottleneck caused by high chloroquine resistance.

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ID Code: 75121
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 6 months
Additional URLs:
Keywords: *Alleles, Animals, Antimalarials/*pharmacology, China/epidemiology, Chloroquine/*pharmacology, Drug Resistance/*genetics, Humans, Malaria, Falciparum/drug therapy/epidemiology/parasitology, Membrane Transport Proteins/*genetics, Plasmodium falciparum/*drug effects/genetics, Prevalence, Protozoan Proteins/*genetics
DOI: 10.1128/AAC.00711-07
ISSN: 0066-4804
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL MICROBIOLOGY (110800) > Medical Parasitology (110803)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Public Health & Social Work
Funding:
  • NIH/5RO1AI47500-06
  • WHO/(WP)/WVP/ICP/MVP/1.4/001
Deposited On: 08 Sep 2014 00:38
Last Modified: 27 Jan 2015 05:18

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