Comparison of ovine mesenchymal cell and osteoblast osteogeic capacity in 2D and 3D

Kim, Margaret (2014) Comparison of ovine mesenchymal cell and osteoblast osteogeic capacity in 2D and 3D. Masters by Research thesis, Queensland University of Technology.

Abstract

This thesis explored the different bone-forming potential of specific bone cells with differing embryological origin, on conventional culture platforms compared to 3D biocompatible scaffolds in vitro. Bone mesenchymal stem cells, mandibular osteoblasts and long bone osteoblasts from adult and juvenile sheep were compared in the study, as the embryological origin of the osteoblasts from the craniofacial and appendicular skeleton differs. The study demonstrated differing characteristics of the various cell types when cultured on the two different platforms compared and this may have an impact on future research into cell seeded tissue scaffolds to aid in vivo tissue regeneration.

Impact and interest:

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Full-text downloads:

39 since deposited on 18 Sep 2014
14 in the past twelve months

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ID Code: 75765
Item Type: QUT Thesis (Masters by Research)
Supervisor: Hutmacher, Dietmar & Vaquette, Cedryck
Keywords: Electrospun meshes, Endochondral bone formation, Intramembranous bone formation, Mesenchymal stem cells, Osteoblasts, Osteogenesis, Osteogenic potential, Polycaprolactone, Tissue engineered scaffolds
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 18 Sep 2014 23:10
Last Modified: 03 Sep 2015 06:03

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