Comparison of eight published static finite element models of the intact lumbar spine : predictive power of models improves when combined together

Dreischarf, M., Zander, T., Shirazi-Adl, A., Puttlitz, C.M., Adam, C.J., Chen, C.S., Goel, V.K., Kiapour, A., Kim, Y.H., Little, J.P., Park, W.M., Labus, K.M., Wang, Y.H., Wilke, H.J., Rohlmann, A., & Schmidt, H. (2014) Comparison of eight published static finite element models of the intact lumbar spine : predictive power of models improves when combined together. Journal of Biomechanics, 47(8), pp. 1757-1766.

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Abstract

Finite element (FE) model studies have made important contributions to our understanding of functional biomechanics of the lumbar spine. However, if a model is used to answer clinical and biomechanical questions over a certain population, their inherently large inter-subject variability has to be considered. Current FE model studies, however, generally account only for a single distinct spinal geometry with one set of material properties. This raises questions concerning their predictive power, their range of results and on their agreement with in vitro and in vivo values.

Eight well-established FE models of the lumbar spine (L1-5) of different research centres around the globe were subjected to pure and combined loading modes and compared to in vitro and in vivo measurements for intervertebral rotations, disc pressures and facet joint forces.

Under pure moment loading, the predicted L1-5 rotations of almost all models fell within the reported in vitro ranges, and their median values differed on average by only 2° for flexion-extension, 1° for lateral bending and 5° for axial rotation. Predicted median facet joint forces and disc pressures were also in good agreement with published median in vitro values. However, the ranges of predictions were larger and exceeded those reported in vitro, especially for the facet joint forces. For all combined loading modes, except for flexion, predicted median segmental intervertebral rotations and disc pressures were in good agreement with measured in vivo values. In light of high inter-subject variability, the generalization of results of a single model to a population remains a concern. This study demonstrated that the pooled median of individual model results, similar to a probabilistic approach, can be used as an improved predictive tool in order to estimate the response of the lumbar spine.

Impact and interest:

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ID Code: 75896
Item Type: Journal Article
Refereed: Yes
Keywords: validation, finite element model, lumbar spine, sensitivity, intersubject variability, sensitivity, predictive power
DOI: 10.1016/j.jbiomech.2014.04.002
ISSN: 0021-9290
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Orthopaedics (110314)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 Elsevier Inc.
Copyright Statement: This is the author’s version of a work that was accepted for publication in Journal of Biomechanics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Biomechanics, [VOL 47, ISSUE 8, (2014)] DOI: 10.1016/j.biomech.2014.04.002
Deposited On: 28 Oct 2014 23:33
Last Modified: 13 Jul 2015 16:08

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