Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes

Fang, Xiaodong, Seim, Inge, Huang, Zhiyong, Gerashchenko, Maxim V., Xiong, Zhiqiang, Turanov, Anton A., Zhu, Yabing, Lobanov, Alexei V., Fan, Dingding, Yim, Sun Hee, Yao, Xiaoming, Ma, Siming, Yang, Lan, Lee, Sang-Goo, Kim, Eun Bae, Bronson, Roderick T., Šumbera, Radim, Buffenstein, Rochelle, Zhou, Xin, Krogh, Anders, Park, Thomas J., Zhang, Guojie, Wang, Jun, & Gladyshev, Vadim N. (2014) Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. Cell Reports, 8(5), pp. 1354-1364.

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Abstract

Subterranean mammals spend their lives in dark, unventilated environments that are rich in carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived and exhibit reduced aging-associated diseases, such as neurodegenerative disorders and cancer. We sequenced the genome of the Damaraland mole rat (DMR, Fukomys damarensis) and improved the genome assembly of the naked mole rat (NMR, Heterocephalus glaber). Comparative genome analyses, along with the transcriptomes of related subterranean rodents, revealed candidate molecular adaptations for subterranean life and longevity, including a divergent insulin peptide, expression of oxygen-carrying globins in the brain, prevention of high CO2-induced pain perception, and enhanced ammonia detoxification. Juxtaposition of the genomes of DMR and other more conventional animals with the genome of NMR revealed several truly exceptional NMR features: unusual thermogenesis, an aberrant melatonin system, pain insensitivity, and unique processing of 28S rRNA. Together, these genomes and transcriptomes extend our understanding of subterranean adaptations, stress resistance, and longevity.

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25 citations in Scopus
24 citations in Web of Science®
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ID Code: 75901
Item Type: Journal Article
Refereed: Yes
Keywords: genomics, longevity, ageing, subterranean, endocrinology
DOI: 10.1016/j.celrep.2014.07.030
ISSN: 2211-1247
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Bioinformatics (060102)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > EVOLUTIONARY BIOLOGY (060300) > Biological Adaptation (060303)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > EVOLUTIONARY BIOLOGY (060300) > Evolutionary Biology not elsewhere classified (060399)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Genomics (060408)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Molecular Evolution (060409)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > PHYSIOLOGY (060600) > Animal Physiology - Systems (060603)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Endocrinology (110306)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2014 The Authors
Copyright Statement: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Deposited On: 03 Sep 2014 22:24
Last Modified: 22 Jun 2017 13:01

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