Characterization of autonomic dysfunction in patients with irritable bowel syndrome by means of heart rate variability studies

Abstract

Objective: To characterize autonomic dysfunction in patients with irritable bowel syndrome (IBS) using heart rate variability (HRV) studies.
Methods: EKG signals were obtained from 35 patients and 18 healthy controls in supine, standing and deep breathing modes. HRV power spectra were analysed.
Results: In the supine position, the very low frequency (VLF) power spectral density (PSD) in IBS patients was significantly higher than in normals. On changing from supine to standing position, the normal controls had raised median PSD.
Conclusion: IBS patients have reduced sympathetic influence on the heart period in response to orthostatic stress and diminished parasympathetic modulation during deep breathing.