Preparation and in vitro release of zein microparticles loaded with prednisolone for oral delivery

Lau, Esther T.L., Johnson, Stuart K., Mikkelsen, Deirdre, Halley, Peter J., & Steadman, Kathryn J. (2012) Preparation and in vitro release of zein microparticles loaded with prednisolone for oral delivery. Journal of Microencapsulation, 29(7), pp. 706-712.

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Abstract

Zein has been proposed as a polymer for targeted-drug delivery via the oral route. Zein microparticles were loaded with prednisolone and evaluated as an oral delivery system. Microparticles were formulated using phase separation. Starting quantities of zein and prednisolone, along with the agitation method and temperature were found to significantly impact drug loading and loading efficiency. Vortex mixing produced the highest drug loading and loading efficiency. Drug release was measured in simulated conditions of the stomach and small intestine using the microparticles made with the method that best improved drug loading. In simulated stomach and small intestine conditions, prednisolone release reached almost 70 over 3 and 4h, respectively. While a clinically relevant dose may be delivered using c. 100mg of zein microparticles, prednisolone release from the microparticles indicates that they may not be suited as a controlled-or targeted-delivery system.

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5 citations in Scopus
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6 citations in Web of Science®

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ID Code: 76172
Item Type: Journal Article
Refereed: Yes
Keywords: Drug loading; Encapsulation; Phase separation; Targeted drug delivery, drug carrier; prednisolone; zein; antiinflammatory agent; prednisolone; zein; article; drug delivery system; drug release; in vitro study; simulation; small intestine; stomach; temperature; vortex motion; chemistry; delayed release formulation; drug scree
DOI: 10.3109/02652048.2012.686527
ISSN: 1464-5246
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Pharmaceutical Sciences (111504)
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Informa
Deposited On: 16 Sep 2014 02:00
Last Modified: 17 Dec 2015 23:57

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