Preparation and in vitro release of zein microparticles loaded with prednisolone for oral delivery
Lau, Esther T.L., Johnson, Stuart K., Mikkelsen, Deirdre, Halley, Peter J., & Steadman, Kathryn J. (2012) Preparation and in vitro release of zein microparticles loaded with prednisolone for oral delivery. Journal of Microencapsulation, 29(7), pp. 706-712.
Zein has been proposed as a polymer for targeted-drug delivery via the oral route. Zein microparticles were loaded with prednisolone and evaluated as an oral delivery system. Microparticles were formulated using phase separation. Starting quantities of zein and prednisolone, along with the agitation method and temperature were found to significantly impact drug loading and loading efficiency. Vortex mixing produced the highest drug loading and loading efficiency. Drug release was measured in simulated conditions of the stomach and small intestine using the microparticles made with the method that best improved drug loading. In simulated stomach and small intestine conditions, prednisolone release reached almost 70 over 3 and 4h, respectively. While a clinically relevant dose may be delivered using c. 100mg of zein microparticles, prednisolone release from the microparticles indicates that they may not be suited as a controlled-or targeted-delivery system.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Keywords:||Drug loading; Encapsulation; Phase separation; Targeted drug delivery, drug carrier; prednisolone; zein; antiinflammatory agent; prednisolone; zein; article; drug delivery system; drug release; in vitro study; simulation; small intestine; stomach; temperature; vortex motion; chemistry; delayed release formulation; drug scree|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Pharmaceutical Sciences (111504)|
|Divisions:||Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2012 Informa|
|Deposited On:||16 Sep 2014 02:00|
|Last Modified:||17 Dec 2015 23:57|
Repository Staff Only: item control page