Unswitch-ABL drugs overcome resistance in chronic myeloid leukemia
Packer, Leisl M. & Marais, Richard (2011) Unswitch-ABL drugs overcome resistance in chronic myeloid leukemia. Cancer Cell, 19(4), pp. 435-437.
ABL inhibitors have revolutionized the clinical management of chronic myeloid leukemia, but the BCR-ABLT315I mutation confers resistance to currently approved drugs. Chan et al. show, in this issue of Cancer Cell, that " switch-control" inhibitors block BCR-ABLT315I activity by preventing ABL from switching from the inactive to active conformation.
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|Item Type:||Journal Article|
|Keywords:||B Raf kinase; calcium ion; phosphodiesterase 5A; phosphodiesterase V; unclassified drug; article; calcium cell level; cancer invasion; cell proliferation; controlled study; down regulation; enzyme regulation; human; human cell; melanoma cell; oncogene N r|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Therapy (excl. Chemotherapy and Radiation Therapy) (111204)
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||23 Sep 2014 23:12|
|Last Modified:||24 Sep 2014 22:12|
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