Unswitch-ABL drugs overcome resistance in chronic myeloid leukemia

Packer, Leisl M. & Marais, Richard (2011) Unswitch-ABL drugs overcome resistance in chronic myeloid leukemia. Cancer Cell, 19(4), pp. 435-437.

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Abstract

ABL inhibitors have revolutionized the clinical management of chronic myeloid leukemia, but the BCR-ABLT315I mutation confers resistance to currently approved drugs. Chan et al. show, in this issue of Cancer Cell, that " switch-control" inhibitors block BCR-ABLT315I activity by preventing ABL from switching from the inactive to active conformation.

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2 citations in Web of Science®

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ID Code: 76307
Item Type: Journal Article
Refereed: Yes
Keywords: B Raf kinase; calcium ion; phosphodiesterase 5A; phosphodiesterase V; unclassified drug; article; calcium cell level; cancer invasion; cell proliferation; controlled study; down regulation; enzyme regulation; human; human cell; melanoma cell; oncogene N r
DOI: 10.1016/j.ccr.2011.03.019
ISSN: 1535-6108
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Therapy (excl. Chemotherapy and Radiation Therapy) (111204)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
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Deposited On: 23 Sep 2014 23:12
Last Modified: 24 Sep 2014 22:12

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