Transcription factories : gene expression in unions?

Sutherland, Heidi & Bickmore, Wendy A. (2009) Transcription factories : gene expression in unions? Nature Reviews Genetics, 10(7), pp. 457-466.

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Transcription is a fundamental step in gene expression, yet it remains poorly understood at a cellular level. Visualization of transcription sites and active genes has led to the suggestion that transcription occurs at discrete sites in the nucleus, termed transcription factories, where multiple active RNA polymerases are concentrated and anchored to a nuclear substructure. However, this concept is not universally accepted. This Review discusses the experimental evidence in support of the transcription factory model and the evidence that argues against such a spatially structured view of transcription. The transcription factory model has implications for the regulation of transcription initiation and elongation, for the organization of genes in the genome, for the co-regulation of genes and for genome instability.

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209 citations in Scopus
202 citations in Web of Science®
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ID Code: 76319
Item Type: Journal Article
Refereed: Yes
Keywords: DNA directed RNA polymerase; RNA polymerase; transcription elongation factor; transfer RNA; binding site; enzyme structure; fluorescence in situ hybridization; gene cluster; gene expression regulation; genetic transcription; genomic instability; human; hu
DOI: 10.1038/nrg2592
ISSN: 1471-0064
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Medical Genetics (excl. Cancer Genetics) (110311)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 23 Sep 2014 22:26
Last Modified: 24 Sep 2014 23:35

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