Intravitreal drug delivery in retinal disease : are we out of our depth?

Thakur, Sachin S., Barnett, Nigel L., Donaldson, Mark J., & Parekh, Harendra S. (2014) Intravitreal drug delivery in retinal disease : are we out of our depth? Expert Opinion on Drug Delivery, 11(10), pp. 1575-1590.

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Abstract

Introduction

With the ever-increasing global burden of retinal disease, there is an urgent need to vastly improve formulation strategies that enhance posterior eye delivery of therapeutics. Despite intravitreal administration having demonstrated notable superiority over other routes in enhancing retinal drug availability, there still exist various significant physical/biochemical barriers preventing optimal drug delivery into the retina. A further complication lies with an inability to reliably translate laboratory-based retinal models into a clinical setting. Several formulation approaches have recently been evaluated to improve intravitreal therapeutic outcomes, and our aim in this review is to highlight strategies that hold the most promise.

Areas covered

We discuss the complex barriers faced by the intravitreal route and examine how formulation strategies including implants, nanoparticulate carriers, viral vectors and sonotherapy have been utilized to attain both sustained delivery and enhanced penetration through to the retina. We conclude by highlighting the advances and limitations of current in vitro, ex vivo and in vivo retinal models in use by researchers globally.

Expert opinion

Various nanoparticle compositions have demonstrated the ability to overcome the retinal barriers successfully; however, their utility is limited to the laboratory setting. Optimization of these formulations and the development of more robust experimental retinal models are necessary to translate success in the laboratory into clinically efficacious outcomes.

Impact and interest:

10 citations in Scopus
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7 citations in Web of Science®

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ID Code: 76334
Item Type: Journal Article
Refereed: Yes
Keywords: drug delivery, intravitreal delivery, nanoparticles, retina, retinal barriers, retinal models
DOI: 10.1517/17425247.2014.927864
ISSN: 1744-7593
Subjects: Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > NANOTECHNOLOGY (100700) > Nanomedicine (100709)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Sensory Systems (110906)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2014 Informa UK, Ltd.
Deposited On: 24 Sep 2014 23:32
Last Modified: 25 Sep 2014 20:13

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