A tissue-engineered humanised xenograft model of human breast cancer-induced bone metastasis and bone colonisation
Thibaudeau, Laure C. (2014) A tissue-engineered humanised xenograft model of human breast cancer-induced bone metastasis and bone colonisation. PhD by Publication, Queensland University of Technology.
This thesis focuses on the development of a humanised mouse model to investigate human breast cancer metastasis to bone, an incurable disease presenting a major medical challenge in our society. The method is based on tissue-engineered constructs with human cells that generate a human bone-like organ within mice. This novel platform is further applied to mimic human-specific mechanisms of breast cancer metastasis and growth in human bone, and in particular the role of specific cell adhesion molecules in this process is closely investigated.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||QUT Thesis (PhD by Publication)|
|Supervisor:||Hutmacher, Dietmar & Taubenberger, Anna|
|Additional Information:||Thesis embargoed until 29 September 2015.|
|Keywords:||breast cancer, bone metastasis, humanised xenograft model, tissue engineering, osteotropism, bone colonisation, integrin, human osteoblast matrix, melt electrospinning|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Institution:||Queensland University of Technology|
|Deposited On:||19 Nov 2014 02:56|
|Last Modified:||03 Sep 2015 05:08|
Repository Staff Only: item control page