A tissue-engineered humanised xenograft model of human breast cancer-induced bone metastasis and bone colonisation

Thibaudeau, Laure C. (2014) A tissue-engineered humanised xenograft model of human breast cancer-induced bone metastasis and bone colonisation. PhD by Publication, Queensland University of Technology.

Abstract

This thesis focuses on the development of a humanised mouse model to investigate human breast cancer metastasis to bone, an incurable disease presenting a major medical challenge in our society. The method is based on tissue-engineered constructs with human cells that generate a human bone-like organ within mice. This novel platform is further applied to mimic human-specific mechanisms of breast cancer metastasis and growth in human bone, and in particular the role of specific cell adhesion molecules in this process is closely investigated.

Impact and interest:

30 citations in Web of Science®
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ID Code: 76411
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Hutmacher, Dietmar & Taubenberger, Anna
Additional Information: Thesis embargoed until 29 September 2015.
Keywords: breast cancer, bone metastasis, humanised xenograft model, tissue engineering, osteotropism, bone colonisation, integrin, human osteoblast matrix, melt electrospinning
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 19 Nov 2014 02:56
Last Modified: 03 Sep 2015 05:08

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