Mismatch negativity in recent-onset and chronic schizophrenia : a current source density analysis
Fulham, W. Ross, Michie, Patricia T., Ward, Philip B., Rasser, Paul E., Todd, Juanita, Johnston, Patrick J., Thompson, Paul M., & Schall, Ulrich (2014) Mismatch negativity in recent-onset and chronic schizophrenia : a current source density analysis. PLoS ONE, 9(6), e100221.
Mismatch negativity (MMN) is a component of the event-related potential elicited by deviant auditory stimuli. It is presumed to index pre-attentive monitoring of changes in the auditory environment. MMN amplitude is smaller in groups of individuals with schizophrenia compared to healthy controls. We compared duration-deviant MMN in 16 recent-onset and 19 chronic schizophrenia patients versus age- and sex-matched controls. Reduced frontal MMN was found in both patient groups, involved reduced hemispheric asymmetry, and was correlated with Global Assessment of Functioning (GAF) and negative symptom ratings. A cortically-constrained LORETA analysis, incorporating anatomical data from each individual's MRI, was performed to generate a current source density model of the MMN response over time. This model suggested MMN generation within a temporal, parietal and frontal network, which was right hemisphere dominant only in controls. An exploratory analysis revealed reduced CSD in patients in superior and middle temporal cortex, inferior and superior parietal cortex, precuneus, anterior cingulate, and superior and middle frontal cortex. A region of interest (ROI) analysis was performed. For the early phase of the MMN, patients had reduced bilateral temporal and parietal response and no lateralisation in frontal ROIs. For late MMN, patients had reduced bilateral parietal response and no lateralisation in temporal ROIs. In patients, correlations revealed a link between GAF and the MMN response in parietal cortex. In controls, the frontal response onset was 17 ms later than the temporal and parietal response. In patients, onset latency of the MMN response was delayed in secondary, but not primary, auditory cortex. However amplitude reductions were observed in both primary and secondary auditory cortex. These latency delays may indicate relatively intact information processing upstream of the primary auditory cortex, but impaired primary auditory cortex or cortico-cortical or thalamo-cortical communication with higher auditory cortices as a core deficit in schizophrenia.
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|Item Type:||Journal Article|
|Additional Information:||This project was funded by a National Health and Medical Research Council of Australia Project Grant, ID 252480. The contents of this article are solely
the responsibility of the authors and do not reflect the views of NHMRC (http://www.nhmrc.gov.au/). Infrastructure support was received from the Hunter Medical
Research Institute (http://www.hmri.com.au/) and the Schizophrenia Research Institute (http://www.schizophreniaresearch.org.au/), which are supported by
infrastructure funding from NSW Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the
|Subjects:||Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Sensory Processes Perception and Performance (170112)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Psychology & Counselling
|Copyright Owner:||Copyright 2014 Fulham et al.|
|Copyright Statement:||This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
|Deposited On:||05 Nov 2014 22:24|
|Last Modified:||06 Nov 2014 01:43|
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