Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma?

Holzapfel, Boris Michael, Chhaya, Mohit Prashant, Melchels, Ferry, Holzapfel, Nina Pauline, Prodinger, Peter Michael, Eisenhart-Rothe, Ruediger, Griensven, Martijn, Schantz, Jan-Thorsten, Rudert, Maximilian, & Hutmacher, Dietmar (2013) Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma? Sarcoma, 153640.

View at publisher


Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infection. Therefore, reconstruction of these defects is still one of the most demanding procedures in orthopaedic surgery. The constraints of common treatment strategies have triggered a need for new therapeutic concepts to design and engineer unparalleled structural and functioning bone grafts. To satisfy the need for long-term repair and good clinical outcome, a paradigm shift is needed from methods to replace tissues with inert medical devices to more biological approaches that focus on the repair and reconstruction of tissue structure and function. It is within this context that the field of bone tissue engineering can offer solutions to be implemented into surgical therapy concepts after resection of bone and soft tissue sarcoma. In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology.

Impact and interest:

5 citations in Scopus
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 76853
Item Type: Journal Article
Refereed: Yes
Keywords: calcium phosphate ceramic; polyurethan; tissue engineering construct; tissue scaffold; unclassified drug; biocompatibility; biodegradability; bone defect; bone graft; bone implant; bone prosthesis; bone remodeling; bone tissue; cell adhesion; cell differe
DOI: 10.1155/2013/153640
ISSN: 1357-714X
Deposited On: 07 Oct 2014 06:59
Last Modified: 02 Sep 2016 03:52

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page