Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection

Ulett, Glen C., Totsika, Makrina, Schaale, Kolja, Carey, Alison J., Sweet, Matthew J., & Schembri, Mark A. (2013) Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection. Current Opinion in Microbiology, 16(1), pp. 100-107.

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Abstract

Urinary tract infections (UTI) are among the most common infectious diseases of humans and are the most common nosocomial infections in the developed world. It is estimated that 40–50% of women and 5% of men will develop a UTI in their lifetime, and UTI accounts for more than 1 million hospitalizations and $1.6 billion in medical expenses each year in the USA. Uropathogenic Escherichia coli (UPEC) is the primary cause of UTI. This review presents an overview of recent discoveries related to the primary virulence factors of UPEC and major innate immune responses to infection of the lower urinary tract. New and emerging themes in UPEC research are discussed in the context of the interface between host and pathogen.

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ID Code: 77384
Item Type: Review
Refereed: Yes
Keywords: urinary tract infection, innate immunity, uropathogenic E. coli
DOI: 10.1016/j.mib.2013.01.005
ISSN: 1369-5274
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Bacteriology (060501)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > IMMUNOLOGY (110700) > Innate Immunity (110707)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Current Opinion in Microbiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Current Opinion in Microbiology, [VOL 16, ISSUE 1, (2013)] DOI: 10.1016/j.mib.2013.01.005
Deposited On: 14 Oct 2014 01:53
Last Modified: 07 Mar 2016 00:55

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