Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance

King, Nathan P, Sakinç, Türkan, Ben Zakour, Nouri L, Totsika, Makrina, Heras, Begoña, Simerska, Pavla, Shepherd, Mark, Gatermann, Sören G, Beatson, Scott A, & Schembri, Mark A (2012) Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance. BMC Microbiology, 12(1), p. 8.

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Abstract

The Gram-positive bacterium Staphylococcus saprophyticus is the second most frequent causative agent of community-acquired urinary tract infections (UTI), accounting for up to 20% of cases. A common feature of staphylococci is colonisation of the human skin. This involves survival against innate immune defenses including antibacterial unsaturated free fatty acids such as linoleic acid which act by disrupting bacterial cell membranes. Indeed, S. saprophyticus UTI is usually preceded by perineal skin colonisation.

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ID Code: 77391
Item Type: Journal Article
Refereed: Yes
DOI: 10.1186/1471-2180-12-8
ISSN: 1471-2180
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 King et al; licensee BioMed Central Ltd
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 09 Oct 2014 23:40
Last Modified: 13 Oct 2014 23:30

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