DSB proteins and bacterial pathogenicity
Heras, Begoña, Shouldice, Stephen R., Totsika, Makrina, Scanlon, Martin J., Schembri, Mark A., & Martin, Jennifer L. (2009) DSB proteins and bacterial pathogenicity. Nature Reviews Microbiology, 7(3), pp. 215-225.
If DNA is the information of life, then proteins are the machines of life — but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.
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|Item Type:||Journal Article|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||10 Oct 2014 00:42|
|Last Modified:||15 Oct 2014 03:30|
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