Virulence properties of asymptomatic bacteriuria Escherichia coli

Mabbett, Amanda N., Ulett, Glen C., Watts, Rebecca E., Tree, Jai J., Totsika, Makrina, Ong, Cheryl-lynn Y., Wood, Jacqueline M., Monaghan, Wayne, Looke, David, Nimmo, Graeme R., Svanborg , Catharina, & Schembri, Mark A. (2009) Virulence properties of asymptomatic bacteriuria Escherichia coli. International Journal of Medical Microbiology, 299(1), pp. 53-63.

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In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E. coli evade immune detection after the establishment of bacteriuria.

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63 citations in Scopus
60 citations in Web of Science®
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ID Code: 77412
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.ijmm.2008.06.003
ISSN: 1438-4221
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 10 Oct 2014 00:09
Last Modified: 15 Oct 2014 03:36

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