Uropathogenic Escherichia coli mediated urinary tract infection

Totsika, Makrina, Gomes Moriel, Danilo, Idris, Adi, Rogers, Benjamin A., Wurpel, Daniel J., Phan, Minh-Duy, Paterson, David L., & Schembri, Mark A. (2012) Uropathogenic Escherichia coli mediated urinary tract infection. Current Drug Targets, 13(11), pp. 1386-1399.

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Abstract

Urinary tract infection (UTI) is among the most common infectious diseases of humans and is the most common nosocomial infection in the developed world. They cause significant morbidity and mortality, with approximately 150 million cases globally per year. It is estimated that 40-50% of women and 5% of men will develop a UTI in their lifetime, and UTI accounts for more than 1 million hospitalizations and $1.6 billion in medical expenses each year in the USA. Uropathogenic E. coli (UPEC) is the primary cause of UTI. This review presents an overview of the primary virulence factors of UPEC, the major host responses to infection of the urinary tract, the emergence of specific multidrug resistant clones of UPEC, antibiotic treatment options for UPEC-mediated UTI and the current state of vaccine strategies as well as other novel anti-adhesive and prophylactic approaches to prevent UTI. New and emerging themes in UPEC research are also discussed in the context of future outlooks.

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ID Code: 77416
Item Type: Review
Refereed: Yes
Keywords: Antibiotic resistance, uropathogenic Escherichia coli, vaccine, virulence, Urinary Tract Infection, UPEC, UTI, bladder infection (cystitis), acute kidney infection (pyelonephritis), pathogens
DOI: 10.2174/138945012803530206
ISSN: 1389-4501
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Bentham Science Publishers
Deposited On: 08 Oct 2014 22:56
Last Modified: 07 Mar 2016 01:21

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