Recommendations for the categorization of germ cell mutagens

Adler, I.-D., Andrae, U., Kreis, P., Neumann, H.-G., Thier, R., & Wild, D. (2000) Recommendations for the categorization of germ cell mutagens. International Archives of Occupational and Environmental Health, 73(6), pp. 428-432.

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Germ cell mutagens are currently classified into three categories in the German List of MAK- and BAT-Values. These categories have been revised and extended in analogy to the new categories for carcinogenic chemicals. Germ cell mutagens produce heritable gene mutations, and heritable structural and numerical chromosome aberrations in germ cells. The original categories 1 and 2 for germ cell mutagens remained unchanged. Two new categories 3 A and 3 B are proposed for chemicals which are suspected to be germ cell mutagens. A new category 5 is proposed for germ cell mutagens with low potency which contribute negligibly to human genetic risk provided the MAK value is observed. The following categories are presented for further discussion. 1. Germ cell mutagens which have been shown to increase the mutant frequency among the progeny of exposed humans. 2. Germ cell mutagens which have been shown to increase the mutant frequency among the progeny of exposed animals. 3 A. Substances which have been shown to induce genetic damage in germ cells of humans or animals, or which are mutagenic in somatic cells and have been shown to reach the germ cells in their active forms. 3 B. Substances which are suspected of being germ cell mutagens because of their genotoxic effects in mammalian somatic cells in vivo or, in exceptional cases in the absence of in vivo data, if they are clearly mutagenic in vitro and structurally related to in vivo mutagens. 4. not applicable (Category 4 was introduced for carcinogenic substances with nongenotoxic modes of action. By definition, germ cell mutagens are genotoxic. Therefore, a Category 4 for germ cell mutagens cannot exist.) 5. Germ cell mutagens, the potency of which is considered to be so low that, provided the MAK value is observed, their contribution to genetic risk is expected not to be significant.

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ID Code: 77436
Item Type: Journal Article
Refereed: Yes
Keywords: Genetic risk, Germ cell mutagens, List of MAK and BAT Values, carcinogen, mutagenic agent, article, chemical mutagenesis, classification, exposure, gene mutation, genotoxicity, germ cell, Germany, human, mutant, nonhuman, numerical chromosome aberration, progeny, somatic cell
DOI: 10.1007/s004200000122
ISSN: 1432-1246
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2000 Springer-Verlag
Deposited On: 17 Oct 2014 01:11
Last Modified: 17 Oct 2014 01:11

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