Occurrence of urinary tract tumors in miners highly exposed to dinitrotoluene

Brüning, Thomas, Chronz, Cordula, Thier, Ricarda, Havelka, Jan, Ko, Yon, & Bolt, Hermann M. (1999) Occurrence of urinary tract tumors in miners highly exposed to dinitrotoluene. Journal of Occupational and Environmental Medicine, 41(3), pp. 144-149.

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Between 1984 and 1997, six cases of urothelial cancer and 14 cases of renal cell cancer occurred in a group of 500 underground mining workers in the copper-mining industry of the former German Democratic Republic, with high exposures to explosives containing technical dinitrotoluene. Exposure durations ranged from 7 to 37 years, and latency periods ranged from 21 to 46 years. The incidences of both urothelial and renal cell tumors in this group were much higher than anticipated on the basis of the cancer registers of the German Democratic Republic by factors of 4.5 and 14.3, respectively. The cancer cases and a representative group of 183 formerly dinitrotoluene- exposed miners of this local industry were interviewed for their working history and grouped into four exposure categories. This categorization of the 14 renal cell tumor cases revealed no dose-dependency concerning explosives in any of the four exposure categories and was similar to that of the representative group of employees, whereas the urothelial tumor cases were predominantly confined to the high-exposure categories. Furthermore, all identified tumor patients were genotyped by polymerase chain reaction, using lymphocyte DNA, regarding their genetic status of the polymorphic xenobiotic metabolizing enzymes, including the N-acetyltransferase 2 and the glutathione-S-transferases M1 and T1. This genotyping revealed remarkable distributions only for the urothelial tumor cases, who were exclusively identified as 'slow acetylators.' This points to the possibility of human carcinogenicity of dinitrotoluene, with regard to the urothelium as the target tissue.

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ID Code: 77447
Item Type: Journal Article
Refereed: Yes
Keywords: acyltransferase, copper, dinitrotoluene, DNA, explosive, glutathione transferase, toluene derivative, unclassified drug, acetylator phenotype, article, cancer incidence, German Democratic Republic, human, human cell, kidney carcinoma, major clinical study, miner, occupational exposure, polymerase chain reaction, retrospective study, urinary tract tumor, Aged, Air Pollutants, Occupational, Carcinoma, Renal Cell, Dinitrobenzenes, Genotype, Germany, East, Humans, Kidney Neoplasms, Middle Aged, Mining, Occupational Diseases, Retrospective Studies, Time Factors, Urologic Neoplasms
ISSN: 1076-2752
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 1999 Lippincott Williams & Wilkins
Deposited On: 21 Oct 2014 02:49
Last Modified: 03 Feb 2015 04:00

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