Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene

Brüning, Thomas, Lammert, Marga, Kempkes, Manuela, Thier, Ricarda, Golka, Klaus, & Bolt, Hermann M. (1997) Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene. Archives of Toxicology, 71(9), pp. 596-599.

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Abstract

Suspected nephrocarcinogenic effects of trichloroethene (TRI) in humans are attributed to metabolites derived from the glutathione transferase (GST) pathway. The influence of polymorphisms of GSTM1 and GSTT1 isoenzymes on the risk of renal cell cancer in subjects having been exposed to high levels of TRI over many years was investigated. GSTM1 and GSTT1 genotypes were determined by internal standard controlled polymerase chain reaction. Fourty-five cases with histologically verified renal cell cancer and a history of long-term occupational exposure to high concentrations of TRI were studied. A reference group consisted of 48 workers from the same geographical region with similar histories of occupational exposures to TRI but not suffering from any cancer. Among the 45 renal cell cancer patients, 27 carried at least one functional GSTM1 (GSTM1 +) and 18 at least one functional GSTT1 (GSTT1 +). Among the 48 reference workers, 17 were GSTM1 + and 31 were GSTT1 +. Odds ratios for renal cell cancer were 2.7 for GSTM1 + individuals (95% CI, 1.18-6.33; P < 0.02) and 4.2 for GSTT1 + individuals (95% CI, 1.16-14.91; P < 0.05), respectively. The data support the present concept of the nephrocarcinogenicity of TRI.

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ID Code: 77448
Item Type: Journal Article
Refereed: Yes
Keywords: Glutathione transferases, GSTM1, GSTT1, Renal cell cancer, Trichloroethene, glutathione transferase, isoenzyme, trichloroethylene, article, cancer risk, controlled study, female, genetic polymorphism, genotype, geography, human, kidney carcinoma, long term exposure, male, metabolite, occupational exposure, polymerase chain reaction, priority journal, Aged, Carcinoma, Renal Cell, Humans, Isoenzymes, Kidney Neoplasms, Middle Aged, Polymorphism, Genetic, Risk Factors, Solvents
DOI: 10.1007/s002040050432
ISSN: 0340-5761
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 1997 Springer
Deposited On: 20 Oct 2014 23:49
Last Modified: 20 Oct 2014 23:49

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