Melatonin synthesis : a possible indicator of intolerance to shiftwork

Griefahn, B., Künemund, C., Golka, K., Thier, R., & Degen, G. (2002) Melatonin synthesis : a possible indicator of intolerance to shiftwork. American Journal of Industrial Medicine, 42(5), pp. 427-436.

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Hypothesis Melatonin synthesis, which is directly controlled by the central circadian pacemaker indicates the circadian phase better than rectal temperature. Methods: Thirty four men (16-32 years, 7 morning, 13 neither, 14 evening types) performed a constant routine (24-26-hr bedrest, < 30 lux, 18-20°C, hourly isocaloric diet). Salivary melatonin level was determined hourly and rectal temperature was continuously recorded. Results: The nadir of rectal temperature occurred 1.5 hr (P = 0.017), the onset of melatonin synthesis 3 hr earlier (P < 0.0001) in morning than in evening types. Morningness was not related to the quantitative but significantly to the temporal parameters, closer to those of melatonin than of rectal temperature. Conclusions: The melatonin onset is a more reliable indicator of the diurnal type than the nadir of rectal temperature. As morningness has been associated with intolerance to shiftwork, melatonin profiling provides a suitable basis for the establishment of directed preventive measures.

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ID Code: 77454
Item Type: Journal Article
Refereed: Yes
Keywords: Constant routine, Diurnal type, Rectal temperature, Salivary melatonin concentrations, Shift work, 6 hydroxymelatonin o sulfate, melatonin, adult, article, circadian rhythm, core temperature, female, hormone determination, hormone synthesis, hormone urine level, human, major clinical study, male, night work, rectum temperature, shift worker, Adaptation, Physiological, Body Temperature, Humans, Middle Aged, Pilot Projects, Questionnaires, Rectum, Saliva, Work Schedule Tolerance
DOI: 10.1002/ajim.10122
ISSN: 0271-3586
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: © 2002 Wiley-Liss, Inc.
Deposited On: 17 Oct 2014 00:51
Last Modified: 17 Oct 2014 00:51

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