Activation of toxic chemicals by cytochrome P450 enzymes : regio- and stereoselective oxidation of aflatoxin B1
Guengerich, F. P., Ueng, Y. F., Kim, B. R., Langouet, S., Coles, B., Iyer, R. S., Thier, R., Harris, T. M., Shimada, T., Yamazaki, H., Ketterer, B., & Guillouzo, A. (1996) Activation of toxic chemicals by cytochrome P450 enzymes : regio- and stereoselective oxidation of aflatoxin B1. Advances in Experimental Medicine and Biology, 387, pp. 7-15.
Cytochrome P450 (P450) enzymes are involved in the oxidations of numerous steroids, eicosanoids, alkaloids, and other endogenous substrates. These enzymes are also the major ones involved in the oxidation of potential toxicants and carcinogens such as those encountered among pollutants, solvents, and pesticides, as well as many natural products. A proper understanding of the basic mechanisms by which the P450 enzymes oxidize such compounds is important in developing rational strategies for the evaluation of the risks of these compounds.
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|Item Type:||Journal Article|
|Keywords:||3 methylcholanthrene, aflatoxin b1, alpha naphthoflavone, cytochrome p450, epoxide, oltipraz, conference paper, epoxidation, genotoxicity, human, human cell, liver cell, liver microsome, metabolic activation, oxidation, priority journal, stereoisomerism, Animals, Biotransformation, Cytochrome P-450 Enzyme System, Humans, Mutagens, Oxidation-Reduction|
|Divisions:||Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
|Copyright Owner:||Copyright 1996 Springer New York LLC|
|Deposited On:||17 Oct 2014 01:04|
|Last Modified:||17 Oct 2014 01:04|
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