Influence of cytochrome P-450 inhibitors on the inhalative uptake of methyl chloride and methylene chloride in male B6C3F1 mice

Ottenwalder, H., Jager, R., Thier, R., & Bolt, H. M. (1989) Influence of cytochrome P-450 inhibitors on the inhalative uptake of methyl chloride and methylene chloride in male B6C3F1 mice. Archives of Toxicology, 13, pp. 258-261.

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Dichloromethane (DCM) is thought to be metabolized in vivo by two independent pathways: a glutathione (GSH) dependent pathway that yields CO2 and a cytochrome P-450 mediated one that yields both CO and CO2 (Gargas et al 1986). With a physiologically based pharmacokinetic (PB-PK) model, Andersen et al (1987) calculate the quantitative parameters for both metabolic pathways. Using the kinetic parameters thus obtained and the results of two carcinogenicity studies with rodents (Serota et al 1986; NTP 1985), the authors then estimate the tumour risk for humans.

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ID Code: 77469
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: cytochrome p450, dichloromethane, diethyldithiocarbamic acid, methyl chloride, pyrazole, chlorinated hydrocarbon, Cytochrome P 450 Enzyme System, glutathione, pyrazole derivative, abstract report, animal experiment, enzyme inhibition, inhalation, intraperitoneal drug administration, male, mouse, nonhuman, priority journal, animal, article, inhalational drug administration, liver, lung, metabolism, mouse strain, Administration, Inhalation, Cytochrome P-450 Enzyme System, Ditiocarb, Hydrocarbons, Chlorinated, Methylene Chloride, Mice, Mice, Inbred Strains, Pyrazoles
DOI: 10.1007/978-3-642-74117-3_45
ISSN: 1432-0738
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 1989 Springer Verlag
Deposited On: 17 Oct 2014 01:17
Last Modified: 22 Jun 2017 23:03

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