Glutathione transferase Ti and M1 genotype polymorphism in the normal population of Shanghai

Shen, Jianhua, Lin, Guofang, Yuan, Wuxing, Tan, Jingwei, Bolt, Hermann M., & Thier, Ricarda (1998) Glutathione transferase Ti and M1 genotype polymorphism in the normal population of Shanghai. Archives of Toxicology, 72(7), pp. 456-458.

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Abstract

Glutathione transferases are known to be important enzymes in the metabolism of xenobiotics. In humans genetic polymorphisms have been reported for the hGSTM1 and hGSTT1 genes leading to individual differences in susceptibility towards toxic effects, such as cancer. This study describes the distribution of the two polymorphisms of hGSTT1 and hGSTM1 in the normal Chinese population of Shanghai. Out of 219 healthy individuals having been genotyped for GSTTI and GSTMI, 108 (49%) were identified to be homozygously deficient for the GSTT1 gene and 107 (49%) for the GSTM1 gene.

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ID Code: 77473
Item Type: Journal Article
Refereed: Yes
Keywords: Glutathione transferase, GSTT1, Polymorphism, STM1, article, china, genetic polymorphism, genotype, homozygosity, priority journal, adult, genetics, human, letter, polymerase chain reaction, Humans, Polymorphism, Genetic
DOI: 10.1007/s002040050528
ISSN: 0340-5761
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 1998 Springer-Verlag
Deposited On: 16 Oct 2014 02:36
Last Modified: 16 Oct 2014 02:36

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