Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma

Steinhoff, Christine, Franke, Knut H., Golka, Klaus, Thier, Ricarda, Römer, Hermann C., Rötzel, Clauda, Ackermann, Rolf, & Schulz, Wolfgang A. (2000) Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma. Archives of Toxicology, 74(9), pp. 521-526.

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Genotype distributions for GSTP1, GSTM1, and GSTT1 were determined in 91 patients with prostatic carcinoma and 135 patients with bladder carcinoma and compared with those in 127 abdominal surgery patients without malignancies. None of the genotypes differed significantly with respect to age or sex among controls or cancer patients. In the group of prostatic carcinoma patients, GSTT1 null allele homozygotes were more prevalent (25% in carcinoma patients vs 13% in controls, Fisher P=0.02, χ2 P = 0.02, OR = 2.31, CI = 1.17-4.59) and the combined M1-/T1-null genotype was also more frequent (9% vs 3%, χ2 P= 0.02, Fisher P = 0.03). Homozygosity for the GSTM1 null allele was more frequent among bladder carcinoma patients (59% in bladder carcinoma patients vs 45% in controls, Fisher P = 0.03, χ2 P = 0.02, OR = 1.76, CI = 1.08-2.88). In contrast to a previous report, no significant increase in the frequency of the GSTP1b allele was found in the tumor patients. Except for the combined GSTM1-/T1-null genotype in prostatic carcinoma, none of the combined genotypes showed a significant association with either of the cancers. These findings suggest that specific single polymorphic GST genes, that is GSTM1 in the case of bladder cancer and GSTT1 in the case of prostatic carcinoma, are most relevant for the development of these urological malignancies among the general population in Central Europe.

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ID Code: 77474
Item Type: Journal Article
Refereed: Yes
Keywords: Bladder cancer, Gene polymorphism, Glutathione transferase, Prostate carcinoma, isoenzyme, adult, aged, allele, article, bladder carcinoma, controlled study, DNA polymorphism, Europe, female, genotype, homozygosity, human, human cell, major clinical study, male, priority journal, Alleles, DNA, Gene Frequency, Humans, Isoenzymes, Middle Aged, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Prostatic Neoplasms, Risk Assessment, Urinary Bladder Neoplasms, Martes pennanti
DOI: 10.1007/s002040000161
ISSN: 03405761 (ISSN)
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2000 Springer
Deposited On: 16 Oct 2014 02:29
Last Modified: 16 Oct 2014 02:29

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