European aspects of standard setting in occupational hygiene and medicine

Thier, Ricarda & Bolt, Hermann M. (2001) European aspects of standard setting in occupational hygiene and medicine. Reviews on Environmental Health, 16(2), pp. 81-86.

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Occupational standards concerning the allowable concentrations of chemical compounds in the ambient air of workplaces have been established in several countries at national levels. With the integration of the European Union, a need exists for establishing harmonized Occupational Exposure Limits. For analytical developments, it is apparent that methods for speciation or fractionation of carcinogenic metal compounds will be of increasing practical importance for standard setting. Criteria of applicability under field conditions, cost-effectiveness, and robustness are practical driving forces for new developments. When the European Union issued a list of 62 chemical substances with Occupational Exposure Limits in 2000, 25 substances received a 'skin' notation. The latter indicates that toxicologically significant amounts may be taken up via the skin. Similar notations exist on national levels. For such substances, monitoring concentrations in ambient air will not be sufficient; biological monitoring strategies will gain further importance in the medical surveillance of workers who are exposed to such compounds. Proceedings in establishing legal frameworks for a biological monitoring of chemical exposures within Europe are paralleled by scientific advances in this field. A new aspect is the possibility of a differential adduct monitoring, using blood proteins of different half-life or lifespan. This technique allows differentiation between long-term mean exposure to reactive chemicals and short-term episodes, for example, by accidental overexposure. For further analytical developments, the following issues have been addressed as being particularly important: New dose monitoring strategies, sensitive and reliable methods for detection of DNA adducts, cytogenetic parameters in biological monitoring, methods to monitor exposure to sensitizing chemicals, and parameters for individual susceptibilities to chemical toxicants.

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ID Code: 77478
Item Type: Journal Article
Refereed: Yes
Keywords: Adduct monitoring, Biological exposure limits, Biological monitoring, Occupational exposure limits, metal derivative, air quality standard, ambient air, cost effectiveness analysis, DNA adduct, European Union, long term exposure, occupational exposure, occupational health, occupational medicine, protein blood level, review, sensitization, toxicology, workplace, DNA Adducts, Europe, Hazardous Substances, Humans, Maximum Allowable Concentration, Monitoring, Physiologic, Program Development, Safety, Skin Absorption
DOI: 10.1515/REVEH.2001.16.2.81
ISSN: 0048-7554
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2001 Walter de Gruyter GmbH
Deposited On: 15 Oct 2014 23:44
Last Modified: 15 Oct 2014 23:44

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