Genetic susceptibility to environmental toxicants : the interface between human and experimental studies in the development of new toxicological concepts

Thier, Ricarda, Golka, Klaus, Bruning, Thomas, Ko, Yon, & Bolt, Hermann M. (2002) Genetic susceptibility to environmental toxicants : the interface between human and experimental studies in the development of new toxicological concepts. Toxicology Letters, 127(1-3), pp. 321-327.

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The growing knowledge of the genetic polymorphisms of enzymes metabolising xenobiotics in humans and their connections with individual susceptibility towards toxicants has created new and important interfaces between human epidemiology and experimental toxicology. The results of molecular epidemiological studies may provide new hypotheses and concepts, which call for experimental verification, and experimental concepts may obtain further proof by molecular epidemiological studies. If applied diligently, these possibilities may be combined to lead to new strategies of human-oriented toxicological research. This overview will present some outstanding examples for such strategies taken from the practically very important field of occupational toxicology. The main focus is placed on the effects of enzyme polymorphisms of the xenobiotic metabolism in association with the induction of bladder cancer and renal cell cancer after exposure to occupational chemicals. Also, smoking and induction of head and neck squamous cell cancer are considered.

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15 citations in Web of Science®

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ID Code: 77485
Item Type: Journal Article
Refereed: Yes
Keywords: Cancer, Genetic susceptibility, Metabolism, enzyme, bladder cancer, bladder carcinogenesis, cancer risk, carcinogenicity, concept formation, conference paper, environmental exposure, enzyme polymorphism, epidemiology, experimentation, genetic polymorphism, genetic risk, head and neck cancer, human, hypothesis, kidney cancer, medical research, occupational cancer, occupational carcinogenesis, occupational exposure, occupational hazard, occupational toxicology, priority journal, risk factor, smoking, toxicology, xenobiotic metabolism, Animals, Carcinogens, Carcinoma, Renal Cell, Cytochrome P-450 Enzyme System, Environmental Pollutants, Epidemiology, Molecular, Genetic Predisposition to Disease, Glutathione Transferase, Head and Neck Neoplasms, Humans, Kidney Neoplasms, Toxicity Tests, Urinary Bladder Neoplasms, Xenobiotics
DOI: 10.1016/S0378-4274(01)00515-X
ISSN: 0378-4274
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 09 Oct 2014 22:59
Last Modified: 09 Oct 2014 22:59

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