Re-evaluation of the effect of smoking on the methylation of N-terminal valine in haemoglobin

Thier, R., Lewalter, J., Selinski, S., & Bolt, H. M. (2001) Re-evaluation of the effect of smoking on the methylation of N-terminal valine in haemoglobin. Archives of Toxicology, 75(5), pp. 270-273.

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In view of the established extrapulmonary cancer sites targeted by smoking a multiplicity of compounds, and mechanisms might be involved. It has been debated that smoking caused increased incidence of N-methylvaline at the N-terminus of haemoglobin. Because this could indicate a relevance of methylating nitrosamines in tobacco smoke, data are presented from an industrial cohort of 35 smokers and 21 non-smokers repeatedly monitored between 1994 and 1999. In general, N-methylvaline adduct levels in haemoglobin of smokers were approximately 50% higher than those of non-smokers. The smoking-induced methylation of haemoglobin is likely to be caused by dimethylnitrosamine (N-nitroso-dimethylamine), a major nitrosamine in side-stream tobacco smoke. The biomonitoring data emphasise the potential value of N-methylvaline as a smoking-related biomarker and call for intensified research on tobacco smoke compounds that lead to macromolecular methylation process.

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ID Code: 77489
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Dimethylnitrosamine, Haemoglobin adducts, N-Alkylvaline, N-Cyanoethylvaline, N-Hydroxyethylvaline, N-Methylvaline, Nitrosamines, Smoking, Tobacco smoke, nitrosamine, valine, amino terminal sequence, article, biological monitoring, cancer risk, chemical carcinogenesis, clinical article, controlled study, hemoglobin determination, human, methylation, priority journal, Cohort Studies, Hemoglobins, Humans, Tobacco Smoke Pollution, Nicotiana tabacum
DOI: 10.1007/s002040100235
ISSN: 1432-0738
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2001 Springer-Verlag
Deposited On: 16 Oct 2014 00:01
Last Modified: 16 Oct 2014 00:01

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