DNA binding study of isophorone in rats and mice

Thier, R., Peter, H., Wiegand, H. J., & Bolt, H. M. (1990) DNA binding study of isophorone in rats and mice. Archives of Toxicology, 64(8), pp. 684-685.

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Following isophorone exposure, in a 2-year study with F344 rats and B6C3F1 mice performed under the National Toxicology Program (NTP), an elevated incidence of tumors was observed in male rats (kidney tumors) and male mice (liver tumors). Female rats and mice showed no elevation of tumor rates by isophorone (NTP 1986).

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4 citations in Web of Science®

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ID Code: 77493
Item Type: Journal Article
Refereed: Yes
Keywords: isophorone, animal experiment, animal tissue, dna binding, female, kidney, letter, liver, male, mouse, nonhuman, priority journal, rat, sex difference, Animal, Cyclohexanones, DNA, Mice, Rats, Rats, Inbred F344, Animalia
DOI: 10.1007/BF01974699
ISSN: 0340-5761
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 1990 Springer
Deposited On: 16 Oct 2014 00:13
Last Modified: 16 Oct 2014 00:13

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