Comparison of GST theta activity in liver and kidney of four species

Thier, Ricarda, Wiebel, Frederike A., Schulz, Thomas G., Hinkel, Andreas, Brüning, Thomas, & Bolt, Hermann M. (1998) Comparison of GST theta activity in liver and kidney of four species. Archives of Toxicology : Diversification in Toxicology — Man and Environment, 20, pp. 471-474.

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Glutathione transferases (GSTs) catalyzing the conjugation of glutathione with electrophilic substrates are important enzymes in the metabolism of xenobiotics. Several isozymes exhibit polymorphisms in humans. The two deletion polymorphisms of hGSTM1 and hGSTT1 result in total loss of enzyme activity in homozygous null genotype (GSTM10 and GSTT10 respectively) individuals (Seidegård et al. 1988; Pemble et al. 1994). Individuals that are heterozygous for hGSTT1 show distinctly lower enzyme activities than individuals carrying two functional alleles of hGSTT1 (Wiebel et al. 1996). A similar effect is conceivable for the hGSTM1 polymorphism but has not been verified so far.

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ID Code: 77497
Item Type: Journal Article
Refereed: Yes
Additional Information: Proceedings of the 1997 EUROTOX Congress Meeting Held in Århus, Denmark, June 25–28, 1997
Keywords: glutathione S-transferase T1, glutathione transferase, glutathione transferase T1, animal, article, comparative study, enzymology, erythrocyte, hamster, human, kidney, liver, metabolism, mouse, rat, Animals, Cricetinae, Erythrocytes, Humans, Mice, Rats
DOI: 10.1007/978-3-642-46856-8_42
ISSN: 0171-9750
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 1998 Springer
Deposited On: 16 Oct 2014 02:02
Last Modified: 16 Oct 2014 02:02

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