Physical mechanism of the compressive response of F-actin networks : significance of crosslinker unbinding events

Li, Tong, Hu, Dean, Yarlagadda, Prasad K., & Gu, YuanTong (2014) Physical mechanism of the compressive response of F-actin networks : significance of crosslinker unbinding events. Theoretical and Applied Mechanics Letters, 4(5), 051006-1.

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A model of crosslinker unbinding is implemented in a highly coarsegrained granular model of F-actin cytoskeleton. We employ this specific granular model to study the mechanisms of the compressive responses of F-actin networks. It is found that the compressive response of F-actin cytoskeleton has dependency on the strain rate. The evolution of deformation energy in the network indicates that crosslinker unbinding events can induce the remodelling of F-actin cytoskeleton in response to external loadings. The internal stress in F-actin cytoskeleton can efficiently dissipate with the help of crosslinker unbinding, which could lead to the spontaneous relaxation of living cells.

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ID Code: 77645
Item Type: Journal Article
Refereed: Yes
Keywords: F-actin cytoskeleton, coarse-grained, crosslinker unbinding, compressive response
DOI: 10.1063/2.1405106
ISSN: 2095-0349
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 American Institute of Physics
Deposited On: 15 Oct 2014 00:36
Last Modified: 16 Oct 2014 14:23

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