Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle

Patel, Pooja, de Boer, Leonore, Timms, Peter, & Huston, Wilhelmina May (2014) Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle. Microbes and Infection, 16(8), pp. 690-694.

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Identification of the HtrA inhibitor JO146 previously enabled us to demonstrate an essential function for HtrA during the mid-replicative phase of the Chlamydia trachomatis developmental cycle. Here we extend our investigations to other members of the Chlamydia genus. C. trachomatis isolates with distinct replicative phase growth kinetics showed significant loss of viable infectious progeny after HtrA was inhibited during the replicative phase. Mid-replicative phase addition of JO146 was also significantly detrimental to Chlamydia pecorum, Chlamydia suis and Chlamydia cavie. These data combined indicate that HtrA has a conserved critical role during the replicative phase of the chlamydial developmental cycle.

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ID Code: 77695
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.micinf.2014.07.003
ISSN: 1286-4579
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Microbes and Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Microbes and Infection, [VOL 18, ISSUE 8, (2014)] DOI: 10.1016/j.micinf.2014.07.003
Deposited On: 16 Oct 2014 00:05
Last Modified: 16 Oct 2014 21:14

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