Growth factors in induction of epithelial-mesenchymal transition and metastasis

Said, Nur Akmarina B.M. & Williams, Elizabeth D. (2011) Growth factors in induction of epithelial-mesenchymal transition and metastasis. Cells Tissues Organs, 193(1-2), pp. 85-97.

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Epithelial to mesenchymal transition (EMT) has gained widespread acceptance over recent years as a mechanism by which normally sessile epithelial tumour cells can move away from the primary tumour and metastasize. This review article examines the role of a number of growth factors in inducing EMT, and the reverse process mesenchymal to epithelial transition. Unique and common intracellular signalling pathways are highlighted. A comprehensive understanding of the regulation of EMT will be critical in manipulating this process to develop novel anti-metastasis therapies.

Impact and interest:

30 citations in Scopus
23 citations in Web of Science®
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ID Code: 77747
Item Type: Journal Article
Refereed: Yes
Keywords: Epithelial to mesenchymal transition, metastasis, growth factors
DOI: 10.1159/000320360
ISSN: 1422-6421
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 16 Oct 2014 06:51
Last Modified: 17 Oct 2014 03:39

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