Potential role of EPB41L3 (Protein 4.1B/Dal-1) as a target for treatment of advanced prostate cancer

Bernkopf, Dominic B & Williams, Elizabeth D. (2008) Potential role of EPB41L3 (Protein 4.1B/Dal-1) as a target for treatment of advanced prostate cancer. Expert Opinion on Therapeutic Targets, 12(7), pp. 845-853.

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Abstract

Background: Loss of erythrocyte membrane protein band 4.1-like 3 (EPB41L3; aliases: protein 4.1B, differentially expressed in adenocarcinoma of the lung-1 (Dal-1)) expression has been implicated in tumor progression. Objective: To evaluate literature describing the role of EPB41L3 in tumorigenesis and metastasis, and to consider whether targeting this gene would be useful in the treatment of prostate cancer.

Methods: A literature review of studies describing EPB41L3 and its aliases was conducted. Online databases (NCBI, SwissProt) were also interrogated to collect further data.

Results/conclusion: A growing body of evidence supports a role for loss of EPB41L3 in tumor progression, including in prostate cancer. Therapeutic strategies that could be harnessed to upregulate EPB41L3 gene expression in prostate cancer cells are currently being developed.

Impact and interest:

13 citations in Scopus
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15 citations in Web of Science®

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ID Code: 77752
Item Type: Journal Article
Refereed: Yes
Keywords: cancer, Dal-1, EPB4113, METASTASIS, methylation, prostate, protein 4.1, tumor suppressor
DOI: 10.1517/14728222.12.7.845
ISSN: 1744-7631
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Informa UK Ltd
Deposited On: 16 Oct 2014 05:31
Last Modified: 17 Oct 2014 04:39

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