Remodelling the malignant phenotype : impact of EMT

Said, Nur Akmarina B.M. & Williams, Elizabeth D. (2009) Remodelling the malignant phenotype : impact of EMT. Drug Discovery Today : Disease Models, 6(1), pp. 21-25.

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Abstract

Epithelial to mesenchymal transition (EMT) is a highly conserved programme of events essential for normal development. As it underpins cell plasticity, migration and invasion in a number of settings it is an attractive concept to apply to the malignant phenotype. Much is known about the molecular events regulating EMT in a number of model organisms, including Drosophila, sea urchin, zebrafish, xenopus and the chick. It is increasingly apparent that EMT is a highly conserved process, and that discoveries made in these systems provide excellent insights into the understanding of the role of EMT in human malignancies.

Impact and interest:

2 citations in Scopus
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ID Code: 77753
Item Type: Journal Article
Refereed: Yes
Keywords: epithelial to mesenchymal transtion (EMT), cell plasticity, cancer metastasis, human malignancies
DOI: 10.1016/j.ddmod.2008.12.002
ISSN: 1740-6757
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 17 Oct 2014 00:40
Last Modified: 20 Oct 2014 02:45

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