NADPH oxidases as regulators of tumor angiogenesis : current and emerging concepts

Coso, Sanja, Harrison, Ian, Harrison, Craig B., Vinh, Antony, Sobey, Christopher G., Drummond, Grant R., Williams, Elizabeth D., & Selemidis, Stavros (2012) NADPH oxidases as regulators of tumor angiogenesis : current and emerging concepts. Antioxidants & Redox Signaling, 16(11), pp. 1229-1247.

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Reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and peroxynitrite are generated ubiquitously by all mammalian cells and have been understood for many decades as inflicting cell damage and as causing cancer by oxidation and nitration of macromolecules, including DNA, RNA, proteins, and lipids.

Recent Advances

A current concept suggests that ROS can also promote cell signaling pathways triggered by growth factors and transcription factors that ultimately regulate cell proliferation, differentiation, and apoptosis, all of which are important hallmarks of tumor cell proliferation and angiogenesis. Moreover, an emerging concept indicates that ROS regulate the functions of immune cells that infiltrate the tumor environment and stimulate angiogenesis, such as macrophages and specific regulatory T cells.

Critical Issues

In this article, we highlight that the NADPH oxidase family of ROS-generating enzymes are the key sources of ROS and, thus, play an important role in redox signaling within tumor, endothelial, and immune cells thereby promoting tumor angiogenesis.

Future Directions

Knowledge of these intricate ROS signaling pathways and identification of the culprit NADPH oxidases is likely to reveal novel therapeutic opportunities to prevent angiogenesis that occurs during cancer and which is responsible for the revascularization after current antiangiogenic treatment.

Impact and interest:

46 citations in Scopus
43 citations in Web of Science®
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ID Code: 77762
Item Type: Journal Article
Refereed: Yes
Keywords: NADPH Oxidases, Tumor angiogenesis, reactive oxygen species , cell damage, cell proliferation, differentiation, apoptosis
DOI: 10.1089/ars.2011.4489
ISSN: 1557-7716
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Mary Ann Liebert, Inc.
Deposited On: 17 Oct 2014 01:15
Last Modified: 21 Oct 2014 04:47

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