Ethnic differences in lipid metabolism in two groups of obese South African women

Punyadeera, C., van der Merwe, M.T., Crowther, N.J., Toman, M., Schlaphoff, G.P., & Gray, I.P. (2001) Ethnic differences in lipid metabolism in two groups of obese South African women. Journal of Lipid Research, 42(5), pp. 760-767.

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Abstract

There is a higher prevalence of ischemic heart disease (IHD) in South African white than black women. The objective of this study was to determine biochemical explanations for this prevalence. The study group contained 15 obese black women (OBW) and 14 obese white women (OWW), ah premenopausal, who were examined after an overnight fast. Anthropometric measurements and blood concentrations of glucose, non-esterified fatty acids (NEFAs), catecholamines, plasminogen activator inhibitor-1, C-peptide, proinsulin, lipograms, cortisol, growth hormone, and post-heparin Lipoprotein Lipase activity were measured during an oral glucose tolerance test (OGTT), Body composition was measured using bioelectrical impedance analysis, and subcutaneous and visceral fat mass were assessed with CT-scans. Visceral fat area was higher in OWW (139.7 +/- 10.7 cm(2)) than in OBW (72.3 +/- 3.9 cm(2)) (P < 0.01), as were fasting and 3 h triglyceride concentrations (P < 0.05 for all). OWW also had higher NEFA levels than OBW at 3 and 4 h compared, with OBW (P < 0.05 for both). Fasting cortisol (266 +/- 24 vs. 197 +/- 19 nmol/l; P < 0.05) was higher in OWW than in OBW. These data demonstrate that OWW have higher visceral fat mass than OBW, which may lead to a more atherogenic fasting and postprandial Lipid profile. The higher cortisol levels of the OWW may promote visceral fat deposition. - Punyadeera, C., M-T. van der Merwe, N.J. Crowther, M. Toman, C. P. Schlaphoff, and I. P. Gray. Ethnic differences in lipid metabolism in two groups of obese South African women.

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ID Code: 77805
Item Type: Journal Article
Refereed: Yes
Additional Information: <Go to ISI>://WOS:000168990700011
Keywords: cortisol, fasting and postprandial triglyceride levels, lipoprotein, lipase, nonesterified fatty acids, visceral abdominal adiposity, subcutaneous adipose-tissue, diabetes-mellitus, plasma-triglycerides, computed-tomography, insulin-resistance, glucose-tolerance, men, white, differentiation, communities
ISSN: 0022-2275
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 23 Oct 2014 00:52
Last Modified: 23 Oct 2014 00:52

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