Metabolic response to a mixed meal in obese and lean women from two South African populations
Punyadeera, Chamindie, Crowther, Nigel J., van der Merwe, Maria-Terésa, Toman, Marketa, Immelman, Andrew Ronnie, Schlaphoff, Glen P., & Gray, Ian Peter (2002) Metabolic response to a mixed meal in obese and lean women from two South African populations. Obesity Research, 10(12), pp. 1207-1216.
Lower lipid and insulin levels are found during a glucose-tolerance test in obese black than obese white South African women. Therefore, β-cell function and lipid metabolism were compared in these populations during a mixed meal.
Research Methods and Procedures
Blood concentrations of glucose, free fatty acids (FFAs), insulin, lipograms, and in vivo FFA oxidation were determined at fasting and for 7 hours after oral administration of a mixed emulsion containing glucose-casein-sucrose-lipid and [1-13C] palmitic acid in 8 lean black women (LBW), 10 obese black women (OBW), 9 lean white women (LWW), and 10 obese white women (OWW). Subcutaneous and visceral fat mass was assessed by computerized tomography.
Visceral fat area was higher in OWW (152.7 ± 17.0 cm2) than OBW (80.0 ± 6.7 cm2; p < 0.01). In OBW, 30-minute insulin levels were higher (604.3 ± 117.6 pM) than OWW (311.0 ± 42.9 pM; p < 0.05). Total triglyceride was higher in OWW (706.7 ± 96.0 mM × 7 hours) than OBW (465.7 ± 48.2 mM × 7 hours; p < 0.05) and correlated with visceral fat area (β = 0.38, p = 0.05). Palmitate oxidation was higher in lean than obese women in both ethnic groups and correlated negatively with fat mass (β = −0.58, p < 0.005).
The higher 30-minute insulin response in OBW may reflect a higher insulinotropic effect of FFAs or glucose. The elevated triglyceride level of OWW may be due to their higher visceral fat mass and possibly reduced clearance by adipose tissue.
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|Item Type:||Journal Article|
|Additional Information:||<Go to ISI>://WOS:000179821300003|
|Keywords:||visceral obesity, in vivo lipid oxidation, triglyceride metabolism, insulin secretion, dependent diabetes-mellitus, subcutaneous adipose-tissue, insulin-resistance, lipoprotein-lipase, ethnic-differences, fat, distribution, computed-tomography, lipid-metabolism, glycerol release, breath tests|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
|Copyright Owner:||Copyright 2002 North American Association for the Study of Obesity (NAASO)|
|Deposited On:||23 Oct 2014 01:04|
|Last Modified:||23 Oct 2014 01:04|
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