Metabolic response to a mixed meal in obese and lean women from two South African populations

Punyadeera, Chamindie, Crowther, Nigel J., van der Merwe, Maria-Terésa, Toman, Marketa, Immelman, Andrew Ronnie, Schlaphoff, Glen P., & Gray, Ian Peter (2002) Metabolic response to a mixed meal in obese and lean women from two South African populations. Obesity Research, 10(12), pp. 1207-1216.

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Abstract

Objective

Lower lipid and insulin levels are found during a glucose-tolerance test in obese black than obese white South African women. Therefore, β-cell function and lipid metabolism were compared in these populations during a mixed meal.

Research Methods and Procedures

Blood concentrations of glucose, free fatty acids (FFAs), insulin, lipograms, and in vivo FFA oxidation were determined at fasting and for 7 hours after oral administration of a mixed emulsion containing glucose-casein-sucrose-lipid and [1-13C] palmitic acid in 8 lean black women (LBW), 10 obese black women (OBW), 9 lean white women (LWW), and 10 obese white women (OWW). Subcutaneous and visceral fat mass was assessed by computerized tomography.

Results

Visceral fat area was higher in OWW (152.7 ± 17.0 cm2) than OBW (80.0 ± 6.7 cm2; p < 0.01). In OBW, 30-minute insulin levels were higher (604.3 ± 117.6 pM) than OWW (311.0 ± 42.9 pM; p < 0.05). Total triglyceride was higher in OWW (706.7 ± 96.0 mM × 7 hours) than OBW (465.7 ± 48.2 mM × 7 hours; p < 0.05) and correlated with visceral fat area (β = 0.38, p = 0.05). Palmitate oxidation was higher in lean than obese women in both ethnic groups and correlated negatively with fat mass (β = −0.58, p < 0.005).

Discussion

The higher 30-minute insulin response in OBW may reflect a higher insulinotropic effect of FFAs or glucose. The elevated triglyceride level of OWW may be due to their higher visceral fat mass and possibly reduced clearance by adipose tissue.

Impact and interest:

12 citations in Scopus
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8 citations in Web of Science®

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ID Code: 77806
Item Type: Journal Article
Refereed: Yes
Additional Information: <Go to ISI>://WOS:000179821300003
Keywords: visceral obesity, in vivo lipid oxidation, triglyceride metabolism, insulin secretion, dependent diabetes-mellitus, subcutaneous adipose-tissue, insulin-resistance, lipoprotein-lipase, ethnic-differences, fat, distribution, computed-tomography, lipid-metabolism, glycerol release, breath tests
DOI: 10.1038/oby.2002.165
ISSN: 1071-7323
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2002 North American Association for the Study of Obesity (NAASO)
Deposited On: 23 Oct 2014 01:04
Last Modified: 23 Oct 2014 01:04

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