Oestrogen-modulated gene expression in the human endometrium

Punyadeera, C., Dassen, H., Klomp, J., Dunselman, G., Kamps, R., Dijcks, F., Ederveen, A., de Goeij, A., & Groothuis, P. (2005) Oestrogen-modulated gene expression in the human endometrium. Cellular and Molecular Life Sciences, 62(2), pp. 239-250.

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To identify key regulatory mechanisms in the growth and development of the human endometrium, microarray analysis was performed on uncultured human endometrium collected during menstruation (M) and the late-proliferative (LATE-P)-phase of the menstrual cycle, as well as after 24 h incubation in the presence of oestradiol (17beta-E2). We demonstrate the expression of novel gene transcripts in the human endometrium. i.e. mucin-9, novel oestrogen-responsive gene transcripts, i.e. gelsolin and flotillin-1, and genes known to be expressed in human endometrium but not yet shown to be oestrogen responsive, i.e. connexin-37 and TFF1/pS2. Genes reported to be expressed during the implantation window and implicated in progesterone action, i.e. secretoglobin family 2A, member 2 (mammaglobin) and homeobox-containing proteins, were up-regulated in uncultured LATE-P-phase endometrium compared to M-phase endometrium. Some gene transcripts are regulated directly by 17beta-E2 alone, others are influenced by the in vivo environment as well. These observations emphasise that the regulation of endometrium maturation by oestrogen entails more then just stimulation of cell proliferation.

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ID Code: 77810
Item Type: Journal Article
Refereed: Yes
Additional Information: <Go to ISI>://WOS:000226983000012
Keywords: steroid hormones, cell differentiation, extracellular matrix, remodelling, angiogenesis, physiology, female reproductive-tract, frizzled related protein, wnt signaling, pathway, breast-cancer, matrix metalloproteinase-26, diethylstilbestrol, des, oocyte donation, messenger-rna, progesterone, implantation
DOI: 10.1007/s00018-004-4435-y
ISSN: 1420-682X
Deposited On: 19 Oct 2014 23:37
Last Modified: 21 Oct 2014 01:49

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