PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer

Tse, Brian Wan-Chi, Cowin, Gary J., Soekmadji, Carolina, Jovanovic, Lidija, Vasireddy, Raja S., Ling, Ming-Tat, Khatri, Aparajita, Liu, Tianqing, Thierry, Benjamin, & Russell, Pamela J. (2015) PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer. Nanomedicine, 10(3), pp. 375-386.

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Evaluate potential of newly-developed, biocompatible iron oxide magnetic nanoparticles (MNPs) conjugated with J591, an antibody to an extracellular epitope of prostate specific membrane antigen (PSMA), to enhance MRI of prostate cancer (PCa).

Materials & Methods

Specific binding to PSMA by J591-MNP was investigated in vitro. MRI studies were performed on orthotopic tumor-bearing NOD.SCID mice 2h and 24hr after intravenous injection of J591-MNPs, or non-targeting MNPs.

Results and Conclusions

In vitro, MNPs did not affect PCa cell viability, and conjugation to J591 did not compromise antibody specificity and enhanced cellular iron uptake. In vivo, PSMA-targeting MNPs increased MR contrast of tumors, but not by non-targeting MNPs. This provides proof-of-concept that PSMA-targeting MNPs have potential to enhance MR detection/localization of PCa.,

Impact and interest:

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ID Code: 77824
Item Type: Journal Article
Refereed: Yes
Additional URLs:
DOI: 10.2217/nnm.14.122
ISSN: 1748-6963
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Future Medicine Ltd
Deposited On: 17 Oct 2014 00:02
Last Modified: 12 Oct 2015 20:58

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