B-lactamase-mediated resistance to antimicrobials : the relationship between genotype and phenotype
Harris, Tegan Maree (2014) B-lactamase-mediated resistance to antimicrobials : the relationship between genotype and phenotype. PhD thesis, Queensland University of Technology.
This thesis examined the ability to predict the emergence of bacteria resistant to antibiotics using genetic markers in the bacteria. Bacteria containing the genetic markers were able to become resistant to antibiotics, whereas bacteria that did not have the genetic markers remained susceptible. Existing techniques can identify the presence of resistance by looking at the characteristics of the bacteria during growth. However, having the ability to predict antibiotic resistance before it emerges could improve the preservation of currently available antibiotics and minimise treatment failure.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Giffard, Philip & Huygens, Flavia|
|Keywords:||b-lactamase, extended-spectrum b-lactamase, blaSHV, blaTEM, minimum inhibitory concentration (MIC), mutation rate, population analysis profile (PAP), inoculum effect, stepwise selection to cefotaxime resistance|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||04 Nov 2014 05:37|
|Last Modified:||02 Sep 2015 06:00|
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