B-lactamase-mediated resistance to antimicrobials : the relationship between genotype and phenotype

Harris, Tegan Maree (2014) B-lactamase-mediated resistance to antimicrobials : the relationship between genotype and phenotype. PhD thesis, Queensland University of Technology.


This thesis examined the ability to predict the emergence of bacteria resistant to antibiotics using genetic markers in the bacteria. Bacteria containing the genetic markers were able to become resistant to antibiotics, whereas bacteria that did not have the genetic markers remained susceptible. Existing techniques can identify the presence of resistance by looking at the characteristics of the bacteria during growth. However, having the ability to predict antibiotic resistance before it emerges could improve the preservation of currently available antibiotics and minimise treatment failure.

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154 since deposited on 04 Nov 2014
61 in the past twelve months

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ID Code: 77835
Item Type: QUT Thesis (PhD)
Supervisor: Giffard, Philip & Huygens, Flavia
Keywords: b-lactamase, extended-spectrum b-lactamase, blaSHV, blaTEM, minimum inhibitory concentration (MIC), mutation rate, population analysis profile (PAP), inoculum effect, stepwise selection to cefotaxime resistance
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 04 Nov 2014 05:37
Last Modified: 02 Sep 2015 06:00

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