Progesterone regulation of implantation-related genes: new insights into the role of oestrogen

Dassen, H., Punyadeera, C., Kamps, R., Klomp, J., Dunselman, G., Dijcks, F., de Goeij, A., Ederveen, A., & Groothuis, P. (2007) Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cellular and Molecular Life Sciences, 64(7-8), pp. 1009-1032.

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Abstract

Genomic profiling was performed on explants of late proliferative phase human endometrium after 24-h treatment with progesterone (P) or oestradiol and progesterone (17 beta-E-2+P) and on explants of menstrual phase endometrium treated with 17 beta-E-2+P. Gene expression was validated with real-time PCR in the samples used for the arrays, in endometrium collected from early and mid-secretory phase endometrium, and in additional experiments performed on new samples collected in the menstrual and late proliferative phase. The results show that late proliferative phase human endometrium is more responsive to progestins than menstrual phase endometrium, that the expression of several genes associated with embryo implantation (i.e. thrombomodulin, monoamine oxidase A, SPARC-like 1) can be induced by P in vitro, and that genes that are fully dependent on the continuous presence of 17 beta-E-2 during P exposure can be distinguished from those that are P-dependent to a lesser extent. Therefore, 17 beta-E-2 selectively primes implantation-related genes for the effects of P.

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ID Code: 77872
Item Type: Journal Article
Refereed: Yes
Keywords: human endometrium, explant cultures, global gene expression, oestradiol, progesterone, endometrial stromal cells, fibroblast growth-factor, menstrual-cycle, vitamin-a, proliferative phase, retinoic acid, expression, receptivity, prolactin, receptor
DOI: 10.1007/s00018-007-6553-9
ISSN: 1420-682X
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2007 Springer
Deposited On: 21 Oct 2014 23:45
Last Modified: 23 Oct 2014 00:13

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