Estrogen and the endometrium: lessons learned from gene expression profiling in rodents and human

Groothuis, P. G., Dassen, Hhnm, Romano, A., & Punyadeera, C. (2007) Estrogen and the endometrium: lessons learned from gene expression profiling in rodents and human. Human Reproduction Update, 13(4), pp. 405-417.

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To date, research into the biological processes and molecular mechanisms associated with endometrial receptivity and embryo implantation has been a focus of attention, whereas the complex events that occur in the human endometrium during the menstrual and proliferative phase under the influence of estrogen have received little attention. The objective of this review is to provide an update of our current understanding of the actions of estrogen on both human and rodent endometrium, with special emphasis on the regulation of uterine growth and cell proliferation, and the value of global gene expression analysis, in increasing understanding of these processes.

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68 citations in Scopus
59 citations in Web of Science®
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ID Code: 77873
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 12 months
Keywords: estradiol, endometrium, uterus, gene profiling, proliferation, serum estradiol concentrations, oocyte donation, receptor-alpha, uterine, receptivity, preimplantation period, regulated genes, menstrual-cycle, high responders, cross-talk, in-vivo
DOI: 10.1093/humupd/dmm009
ISSN: 1355-4786
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2007 Oxford University Press
Deposited On: 21 Oct 2014 23:55
Last Modified: 30 Jan 2015 05:21

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