Oral contraceptives prevent the development of endometriosis in the chicken chorioallantoic membrane model

Nap, A. W., Groothuis, P. G., Punyadeera, Chamindie, Klein-Hitpass, L., Kamps, R., Delvoux, B., & Dunselman, G. A. J. (2008) Oral contraceptives prevent the development of endometriosis in the chicken chorioallantoic membrane model. Contraception, 78(3), pp. 257-265.

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Background: Fundamental and genetic differences between women in the endometrium may cause some to develop endometriosis, whereas others (to not. Oral contraceptives (OC) may have in effect on the endometrium, rendering the development of endometriosis less likely. Study Design: Endometrium front women using CC (OCE) and menstrual endometrium (ME) from normal cycling women were transplanted onto the chicken chorioallantoic membrane (CAM), and endometriosis-like lesion formation was evalualed. Microarray gene expression profiling was performed to identify, differentially expressed genes in the endometrium front these groups. Microarray data were validated by real-time PCR. Results: Less endometriosis-like lesions were formed after transplantation of OCE than after transplantation of ME (p<.05). Most of the differentially expressed genes belong to the TGF beta superfamily. Real-time PCR validation revealed that inhibin beta A (INHBA) expression was significantly decreased in OCE its compared to ME. Conclusion: OC use affects the characteristics Of endometrium, rendering it less potent to develop into endometriosis. (C) 2008 Elsevier Inc. All rights reserved.

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ID Code: 77876
Item Type: Journal Article
Refereed: Yes
Keywords: chorioallantoic membrane model, endometrium, endometriosis, microarray, analysis, oral contraceptives, growth-factor-beta, menstrual-cycle, activin-a, inhibin-b, follicular-fluid, women, reproduction, follistatin, tissue, risk
DOI: 10.1016/j.contraception.2008.05.003
ISSN: 0010-7824
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2008 Elsevier Inc.
Deposited On: 22 Oct 2014 00:13
Last Modified: 23 Oct 2014 00:40

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