A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity
Punyadeera, Chamindie, Schneider, E. Marion, Schaffer, Dave, Hsu, Hsin-Yun, Joos, Thomas O., Kriebel, Fabian, Weiss, Manfred, & Verhaegh, Wim F. J. (2010) A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity. Journal of Emergencies, Trauma and Shock, 3(1), pp. 26-35.
Introduction: In this study, we report on initial efforts to discover putative biomarkers for differential diagnosis of a systemic inflammatory response syndrome (SIRS) versus sepsis; and different stages of sepsis. In addition, we also investigated whether there are proteins that can discriminate between patients who survived sepsis from those who did not.
Materials and Methods: Our study group consisted of 16 patients, of which 6 died and 10 survived. We daily measured 28 plasma proteins, for the whole stay of the patients in the ICU.
Results: We observed that metalloproteinases and sE-selectin play a role in the distinction between SIRS and sepsis, and that IL-1, IP-10, sTNF-R2 and sFas appear to be indicative for the progression from sepsis to septic shock. A combined measurement of MMP-3, -10, IL-1, IP-10, sIL-2R, sFas, sTNF-R1, sRAGE, GM-CSF, IL-1 and Eotaxin allows for a good separation of patients that survived from those that died (mortality prediction with a sensitivity of 79% and specificity of 86%). Correlation analysis suggests a novel interaction between IL-1a and IP-10.
Conclusion: The marker panel is ready to be verified in a validation study with or without therapeutic intervention.
Impact and interest:
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|Item Type:||Journal Article|
|Additional Information:||Cited By (since 1996):21
Export Date: 14 October 2014
Correspondence Address: Punyadeera, C.; Department of Molecular Diagnostics, Philips Research, High Tech Campus 12a, 5656 AE Eindhoven, Netherlands; email: firstname.lastname@example.org
|Keywords:||Biomarker, Cellular mechanism, Sepsis outcome, Sepsis stage, SIRS|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2010 Medknow Publications and Media Pvt. Ltd.|
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|Deposited On:||22 Oct 2014 00:04|
|Last Modified:||23 Oct 2014 02:01|
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