A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity

Punyadeera, Chamindie, Schneider, E. Marion, Schaffer, Dave, Hsu, Hsin-Yun, Joos, Thomas O., Kriebel, Fabian, Weiss, Manfred, & Verhaegh, Wim F. J. (2010) A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity. Journal of Emergencies, Trauma and Shock, 3(1), pp. 26-35.

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Abstract

Introduction: In this study, we report on initial efforts to discover putative biomarkers for differential diagnosis of a systemic inflammatory response syndrome (SIRS) versus sepsis; and different stages of sepsis. In addition, we also investigated whether there are proteins that can discriminate between patients who survived sepsis from those who did not.

Materials and Methods: Our study group consisted of 16 patients, of which 6 died and 10 survived. We daily measured 28 plasma proteins, for the whole stay of the patients in the ICU.

Results: We observed that metalloproteinases and sE-selectin play a role in the distinction between SIRS and sepsis, and that IL-1, IP-10, sTNF-R2 and sFas appear to be indicative for the progression from sepsis to septic shock. A combined measurement of MMP-3, -10, IL-1, IP-10, sIL-2R, sFas, sTNF-R1, sRAGE, GM-CSF, IL-1 and Eotaxin allows for a good separation of patients that survived from those that died (mortality prediction with a sensitivity of 79% and specificity of 86%). Correlation analysis suggests a novel interaction between IL-1a and IP-10.

Conclusion: The marker panel is ready to be verified in a validation study with or without therapeutic intervention.

Impact and interest:

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ID Code: 77923
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):21
Export Date: 14 October 2014
Correspondence Address: Punyadeera, C.; Department of Molecular Diagnostics, Philips Research, High Tech Campus 12a, 5656 AE Eindhoven, Netherlands; email: c.punyadeera@uq.edu.au
Keywords: Biomarker, Cellular mechanism, Sepsis outcome, Sepsis stage, SIRS
DOI: 10.4103/0974-2700.58666
ISSN: 0974-2700
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Medknow Publications and Media Pvt. Ltd.
Copyright Statement: The entire contents of the Journal of Postgraduate Medicine are protected under Indian and international copyrights. The Journal, however, grants to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, perform and display the work publicly and to make and distribute derivative works in any digital medium for any reasonable non-commercial purpose, subject to proper attribution of authorship and ownership of the rights. The journal also grants the right to make small numbers of printed copies for their personal non-commercial use under Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License.
Deposited On: 22 Oct 2014 00:04
Last Modified: 23 Oct 2014 02:01

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