Diagnostic potential of saliva : current state and future applications

Pfaffe, Tina, Cooper-White, Justin, Beyerlein, Peter, Kostner, Karam, & Punyadeera, Chamindie (2011) Diagnostic potential of saliva : current state and future applications. Clinical Chemistry, 57(5), pp. 675-687.

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Abstract

BACKGROUND: Over the past 10 years, the use of saliva as a diagnostic fluid has gained attention and has become a translational research success story. Some of the current nanotechnologies have been demonstrated to have the analytical sensitivity required for the use of saliva as a diagnostic medium to detect and predict disease progression. However, these technologies have not yet been integrated into current clinical practice and work flow.

CONTENT: As a diagnostic fluid, saliva offers advantages over serum because it can be collected noninvasively by individuals with modest training, and it offers a cost-effective approach for the screening of large populations. Gland-specific saliva can also be used for diagnosis of pathology specific to one of the major salivary glands. There is minimal risk of contracting infections during saliva collection, and saliva can be used in clinically challenging situations, such as obtaining samples from children or handicapped or anxious patients, in whom blood sampling could be a difficult act to perform. In this review we highlight the production of and secretion of saliva, the salivary proteome, transportation of biomolecules from blood capillaries to salivary glands, and the diagnostic potential of saliva for use in detection of cardiovascular disease and oral and breast cancers. We also highlight the barriers to application of saliva testing and its advancement in clinical settings.

SUMMARY: Saliva has the potential to become a first-line diagnostic sample of choice owing to the advancements in detection technologies coupled with combinations of biomolecules with clinical relevance. (C) 2011 American Association for Clinical Chemistry

Impact and interest:

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ID Code: 77924
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 12 months
Times Cited: 66
Pfaffe, Tina Cooper-White, Justin Beyerlein, Peter Kostner, Karam Punyadeera, Chamindie
Queensland Government; University of Queensland [601252]; Australian Research Council
C.K. Punyadeera, Queensland Government Smart Futures Fellowship Programme (QGSFF), University of Queensland New Staff Research Funds (UQNSRSF 601252), and Australian Research Council Linkage Grant Scheme.
Keywords: c-reactive protein, 2-dimensional gel-electrophoresis, acute, myocardial-infarction, primary sjogrens-syndrome, mass-spectrometry, biomarker discovery, clinical-relevance, immunoglobulin-a, breast-cancer, identification
DOI: 10.1373/clinchem.2010.153767
ISSN: 0009-9147
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 The American Association for Clinical Chemistry
Deposited On: 22 Oct 2014 00:18
Last Modified: 29 Jan 2015 05:48

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