Saliva as an emerging biofluid for clinical diagnosis and applications of MEMS/NEMS in salivary diagnostics

Punyadeera, Chamindie & Slowey, Paul D. (2012) Saliva as an emerging biofluid for clinical diagnosis and applications of MEMS/NEMS in salivary diagnostics. In Subramani, K., Ahmed, W., & Hartsfield, J. K. (Eds.) Nanobiomaterials in Clinical Dentistry. William Andrew [Elsevier], Oxford , UK, pp. 453-473.

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Abstract

Saliva as a biological fluid is gaining wider acceptance for diagnosing diseases. The growing interest in saliva as a biological fluid is due to its noninvasiveness, ease of use, cost-effectiveness, and multiple sample collection possibilities as well as minimal risk to health care professionals of contracting infectious organisms such as HIV and Hep B. However, the clinical translation of saliva is hampered by our lack of understanding of the biomolecular transportation from blood into saliva, the diurnal variations of biomolecules present in saliva, and relatively low levels of analytes (100th to a 1000th fold less than in blood). We provide information on the current status of salivary research, salivary diagnostics empowered by nanotechnology, and future prospects in this emerging field of saliva diagnostics.

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3 citations in Scopus
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ID Code: 77959
Item Type: Book Chapter
Additional Information: No file attached.
Keywords: c-reactive protein, squamous-cell carcinoma, proteomic analysis, anxiety, disorders, plasma proteomes, dna methylation, neck-cancer, oral fluid, flow-rate, biomarkers
DOI: 10.1016/B978-1-4557-3127-5.00022-2
ISBN: 9781455731299; 9781455731275
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright © 2013 Elsevier Inc. All rights reserved
Deposited On: 22 Oct 2014 23:56
Last Modified: 28 Oct 2015 16:37

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