Profiling of immunoglobulins in resting and mechanically stimulated saliva

MacDonald, M., Ab Ghani, N. A., Wan, Y. X., Cooper-White, J., Dimeski, G., & Punyadeera, Chamindie (2014) Profiling of immunoglobulins in resting and mechanically stimulated saliva. Bioanalysis, 6(5), pp. 697-704.

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Background: Dysregulation of salivary immunoglobulins has been implicated in illnesses ranging from periodontal disease to HIV aids and malignant cancers. Despite these advances there is a lack of agreement among studies with regard to the salivary immunoglobulin levels in healthy controls. Methodology: Resting and mechanically stimulated saliva samples and matching serum samples were collected from healthy individuals (n = 33; 40-55 years of age; gender: 23 female, 10 male). A matrix-matched AlphaLISA((R)) assay was developed to determine the concentrations of IgG1 and IgG4 in serum and saliva samples. Conclusion: Clear relationships were observed in the flow rate and concentration of each immunoglobulin in the two types of saliva. This study affirms the need to establish and standardize collection methods before salivary IgGs are used for diagnostic purposes.

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ID Code: 77962
Item Type: Journal Article
Refereed: Yes
Keywords: intimate partner violence, age-related-changes, igg subclasses, parotid-saliva, serum, antibodies, individuals, infection, women, risk
DOI: 10.4155/bio.14.21
ISSN: 1757-6180
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2014 Future Science Ltd.
Deposited On: 23 Oct 2014 01:48
Last Modified: 23 Jun 2017 02:02

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