Profiling of immunoglobulins in resting and mechanically stimulated saliva
MacDonald, M., Ab Ghani, N. A., Wan, Y. X., Cooper-White, J., Dimeski, G., & Punyadeera, Chamindie (2014) Profiling of immunoglobulins in resting and mechanically stimulated saliva. Bioanalysis, 6(5), pp. 697-704.
Background: Dysregulation of salivary immunoglobulins has been implicated in illnesses ranging from periodontal disease to HIV aids and malignant cancers. Despite these advances there is a lack of agreement among studies with regard to the salivary immunoglobulin levels in healthy controls. Methodology: Resting and mechanically stimulated saliva samples and matching serum samples were collected from healthy individuals (n = 33; 40-55 years of age; gender: 23 female, 10 male). A matrix-matched AlphaLISA((R)) assay was developed to determine the concentrations of IgG1 and IgG4 in serum and saliva samples. Conclusion: Clear relationships were observed in the flow rate and concentration of each immunoglobulin in the two types of saliva. This study affirms the need to establish and standardize collection methods before salivary IgGs are used for diagnostic purposes.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Keywords:||intimate partner violence, age-related-changes, igg subclasses, parotid-saliva, serum, antibodies, individuals, infection, women, risk|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Copyright Owner:||Copyright 2014 Future Science Ltd.|
|Deposited On:||23 Oct 2014 01:48|
|Last Modified:||23 Oct 2014 21:11|
Repository Staff Only: item control page