Subclinical psychotic experiences in healthy young adults : associations with stress and genetic predisposition

Bruenig, Dagmar, White, Melanie J., Young, Ross McD, & Voisey, Joanne (2014) Subclinical psychotic experiences in healthy young adults : associations with stress and genetic predisposition. Genetic Testing and Molecular Biomarkers, 18(10), pp. 683-689.

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Abstract

Stress has been identified as a common trigger for psychosis. Dopamine pathways are suggested to be affected by chronic and severe stress and to play an important role in psychosis. This pilot study investigates the potential relationship of stress and psychosis in subclinical psychotic experiences. It was hypothesized that single-nucleotide polymorphisms (SNPs) previously found to be associated with psychiatric disorders would be associated with both stress and subclinical psychotic experiences. University students (N=182) were genotyped for 17 SNPs across 11 genes. Higher stress reporting was associated with rs4680 COMT, rs13211507 HLA region, and rs13107325 SLC39A8. Reports of higher subclinical psychotic experiences were associated with DRD2 SNPs rs17601612 and rs658986 and an AKT1 SNP rs2494732. Replication studies are recommended to further pursue this line of research for identification of markers of psychosis for early diagnosis and intervention.

Impact and interest:

3 citations in Scopus
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3 citations in Web of Science®

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ID Code: 78014
Item Type: Journal Article
Refereed: Yes
Keywords: subclinical psychotic experiences, stress, COMT, DRD2, AKT1, HLA Region
DOI: 10.1089/gtmb.2014.0111
ISSN: 1945-0257
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Gene Expression (incl. Microarray and other genome-wide approaches) (060405)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Neurogenetics (060410)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Mental Health (111714)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Copyright Owner: Copyright 2014 Mary Ann Liebert, Inc.
Copyright Statement: This is a copy of an article published in Genetic Testing and Molecular Biomarkers, copyright Mary Ann Liebert, Inc.; Genetic Testing and Molecular Biomarkers is available online at: http://online.liebertpub.com.
Deposited On: 23 Oct 2014 23:00
Last Modified: 27 Oct 2014 20:10

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