Epigenetics and migraine; complex mitochondrial interactions contributing to disease susceptibility

Roos-Araujo, Deidré, Stuart, Shani, Lea, Rod A., Haupt, Larisa M., & Griffiths, Lyn R. (2014) Epigenetics and migraine; complex mitochondrial interactions contributing to disease susceptibility. Gene, 543(1), pp. 1-7.

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Abstract

Migraine is a common neurological disorder classified by the World Health Organisation (WHO) as one of the top twenty most debilitating diseases in the developed world. Current therapies are only effective for a proportion of sufferers and new therapeutic targets are desperately needed to alleviate this burden. Recently the role of epigenetics in the development of many complex diseases including migraine has become an emerging topic. By understanding the importance of acetylation, methylation and other epigenetic modifications, it then follows that this modification process is a potential target to manipulate epigenetic status with the goal of treating disease. Bisulphite sequencing and methylated DNA immunoprecipitation have been used to demonstrate the presence of methylated cytosines in the human D-loop of mitochondrial DNA (mtDNA), proving that the mitochondrial genome is methylated. For the first time, it has been shown that there is a difference in mtDNA epigenetic status between healthy controls and those with disease, especially for neurodegenerative and age related conditions. Given co-morbidities with migraine and the suggestive link between mitochondrial dysfunction and the lowered threshold for triggering a migraine attack, mitochondrial methylation may be a new avenue to pursue. Creative thinking and new approaches are needed to solve complex problems and a systems biology approach, where multiple layers of information are integrated is becoming more important in complex disease modelling.

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4 citations in Web of Science®

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ID Code: 78031
Item Type: Journal Article
Refereed: Yes
Keywords: Migraine; Epigenetics; Mitochondrial methylation; Disease susceptibility
DOI: 10.1016/j.gene.2014.04.001
ISSN: 0378-1119
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Elsevier B.V.
Copyright Statement: NOTICE: this is the author’s version of a work that was accepted for publication in Gene. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Gene, Volume 543, Issue 1, (10 June 2014), DOI: 10.1016/j.gene.2014.04.001
Deposited On: 27 Oct 2014 00:31
Last Modified: 25 Jun 2015 20:35

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